I use reStructuredText for both this blog and the MetaBrite DevBlog. This blog is built with Acrylamid, while the MetaBrite blog is built with Nikola.
Yesterday I used a link (~/.pgpass) that styled the link as an inline literal; i.e., in the code font. ReStructuredText doesn’t support nested markup, but you can pull it together with a two-step substitution reference:
Here you have |optparse.OptionParser|_. .. |optparse.OptionParser| replace:: ``optparse.OptionParser`` documentation .. _optparse.OptionParser: http://docs.python.org/library/optparse.html
This is tedious as you have to create a pair of directives for every such link that you wish to style.
Nested inline markup has been on the todo list for 15 years—it ain’t happening.